Clinical Pediatrics: Open Access
Open Access
ISSN: 2572-0775
+44 1223 790975
ISSN: 2572-0775
+44 1223 790975
Department of Neonatology, Shaare Zedek Medical Center , M.K. Emeritus, Jerusalem, Israel
Research Article
Differential Expression of Tumor Necrosis Factor-Related Apoptosis Inducing Ligand (TNF-TRAIL) and Interferon-gamma Inducible Protein (IP-10) Biomarker Levels in Neonatal Infections: Potential Role in Ruling out Bacterial Infections to Promote Antibiotic Stewardship
Author(s): Deema Arow Zahalka*
Background: Fever is the most common cause for neonates visiting the Emergency Room (ER). Because bacterial versus viral infection symptoms exhibited by neonates are similar, clinical assessment and history taking are usually
insufficient to distinguish etiology, even for experienced doctors. This clinical uncertainty drives antibiotic misuse,
unwarranted invasive diagnostic procedures and longer hospitalizations.
Methods: A prospective study conducted at Hillel Yaffe Medical Center from 2019 to 2021 to investigate the
expression of three serum proteins: Tumor Necrosis Factor-Related Apoptosis Inducing Ligand (TNF-TRAIL),
interferon gamma-Induced Protein-10 (IP-10) and C-Reactive Protein (CRP) in neonates up to three months of age
with microbiologically confirmed bacterial infections versus viral infection... View More»
DOI:
10.35248/2572-0775.24.09.257