ISSN: 2736-6588
+44 1223 790975
Department of Public Health and Community Medicine, Cairo University, Cairo, Egypt
Research Article
Methylenetetrahydrofolate Reductase C677T Gene Mutation as a Risk Factor for Diabetic Nephropathy
Author(s): Dalia Ahmed*
Background: Methylenetetrahydrofolate Reductase (MTHFR) is a regularly enzyme of homocysteine metabolism.
Point mutation in MTHFR and hyperhomocyteinemia are implicated in the pathogenesis of Diabetic Nephropathy
(DN) in many ethnic groups. The aim of this study is to find if MTHFR C677T polymorphism is a risk factor of DN
in Type 2 Diabetes Mellitus (T2DM) patients.
Subjects and methods: The MTHFR C677T polymorphism was detected in 122 T2DM patients by PCR-RFLP. They
were divided into 3 groups; 75 patients with normoalbuminuria. 33 patients with microalbuminuria and 14 patients
with macroalbuminuria. Seum levels of Homocysteine (HCY) were determined by nephelometry.
Results: Presence of MTHFR C677T allele increase the risk of macroalbuminuria 2.6 folds (p=0.009) in T2DM
patients. The presence of mut.. View More»
DOI:
10.35248/jcclm.21.4.180