Journal of Clinical Chemistry and Laboratory Medicine

Journal of Clinical Chemistry and Laboratory Medicine
Open Access

ISSN: 2736-6588

+44 1223 790975

Dalia Ahmed

Department of Public Health and Community Medicine, Cairo University, Cairo, Egypt

  • Research Article   
    Methylenetetrahydrofolate Reductase C677T Gene Mutation as a Risk Factor for Diabetic Nephropathy
    Author(s): Dalia Ahmed*

    Background: Methylenetetrahydrofolate Reductase (MTHFR) is a regularly enzyme of homocysteine metabolism. Point mutation in MTHFR and hyperhomocyteinemia are implicated in the pathogenesis of Diabetic Nephropathy (DN) in many ethnic groups. The aim of this study is to find if MTHFR C677T polymorphism is a risk factor of DN in Type 2 Diabetes Mellitus (T2DM) patients. Subjects and methods: The MTHFR C677T polymorphism was detected in 122 T2DM patients by PCR-RFLP. They were divided into 3 groups; 75 patients with normoalbuminuria. 33 patients with microalbuminuria and 14 patients with macroalbuminuria. Seum levels of Homocysteine (HCY) were determined by nephelometry. Results: Presence of MTHFR C677T allele increase the risk of macroalbuminuria 2.6 folds (p=0.009) in T2DM patients. The presence of mut.. View More»
    DOI: 10.35248/jcclm.21.4.180

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