Journal of Clinical and Cellular Immunology
Open Access

Department of Isotope Application, Institute of Nuclear Energy Research, Taoyuan (ROC), Taiwan

Publications

• Research Article   
  Imaging the Cytokine Receptor CXCR4 in Atherosclerotic Plaques with [68Ga]-APD: A Novel Agent on Computer Simulation Approach
  Author(s): Chien-Chung Hsia*, Chung-Hsin Yeh, Chun-Tang Chen and Cheng Liang Peng
  
  Introduction: C-X-C motif chemokine receptor 4 (CXCR4) plays a prominent role in inflammation, atherosclerosis, and cancer biology. Therefore, CXCR4 represents a promising target for molecular imaging in cardiovascular diseases such as atherosclerosis and arterial wall injury.CXCR4 and its cognate ligand, stromal cell–derived factor 1α (SDF- 1α), induced monocyte recruitment to the injured endothelium and subsequent plaque formation is the crucial progression of atherosclerosis. CXCR4 was been proved to be intensively expressed on monocytes/macrophage. [68Ga]-APD, based on CXCR4 antagonists TIQ-15, had designed as a PET tracer for imaging atherosclerosis. The aim of this study was to evaluate the biological characteristics of [68Ga]-APD, and compared with [18F]-FDG, [18F]- NaF, and [.. View More»
  DOI: 10.35248/2155-9899.22.13.667

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