Journal of Applied Pharmacy

Journal of Applied Pharmacy
Open Access

ISSN: 1920-4159

Chandrakant Magdum

Department of Pharmacology, Rajarambapu College of Pharmacy, Kasegaon, Sangli, Maharashtra, India

  • Research Article   
    Hepatoprotective Effect of Ethanolic Extracts of Allophylus Cobbe (L.) Raeusch Leaves against Paracetamol Induced Hepatotoxicity in Rats
    Author(s): Sandeep Chavan*, Remeth Dias and Chandrakant Magdum

    Objective: Aim of the current investigation is to screen the hepatoprotective activity of the Ethanolic Extract of Allophylus Cobbe (EEAC) leaves against Paracetamol (PCM) induced hepatotoxicity in rats. Methods: EEAC was administered to the rats for 7 days (200 mg/kg and 400 mg/kg) and hepatotoxicity was induced by administration of PCM (3 g/k day . After 24 h of toxicity induction, the blood samples were collected by retro orbital plexus method and different serum and tissue biochemical parameters were analyzed. Livers of the animals were isolated and were studied for histopathological changes. The extract treated animals were compared with Silymarin (100 mg/kg). Results: Treatment of animals with EEAC at 200 and 400 mg/kg showed dose dependant significant decrease in Serum Glutamate Oxaloacetate Transaminase (SGOT), Serum Glutamate Pyruv.. View More»
    DOI: 10.35248/1920-4159.21.13.300

    Abstract HTML PDF