Cell & Developmental Biology
Open Access
ISSN: 2168-9296
ISSN: 2168-9296
Department of Internal Medicine, University of Zambia, University Teaching Hospital, Lusaka, Zambia
Research Article
A Systematic Protocol for Reviewing and Publishing Papers on the GLUT4 Transporters Polymorphism Influence on the Onset of Type 2 Diabetes in HIV Positive Persons
Author(s): Chitoti Lumbala John*, Monde Wamunyima Mercy, Munsaka Sody, Aubrey Kalungia, Brown Kamanga, Kaampwe Muzandu, Sepiso Masenga and Kanyengo Wamunyima Christine
Background: People living with HIV have a greater prevalence of type 2 diabetes than the overall general population. This increasing occurrence can be attributed to a variety of causes, including the use of specific antiretroviral drugs, chronic metabolic dysfunction associated with HIV infection and lifestyle choices such as poor diet and physical inactivity. The growing number of people living with HIV and developing type 2 diabetes underscores the importance of identifying genetic factors that may influence the disease’s development. When blood glucose rises after a meal, the pancreas secretes insulin. Insulin then binds to its receptor causing translocation of GLUT4 from intracellular vesicles. This leads to blood glucose uptake into the cell's cytoplasm, inside the cell, glucose is converted to energy and stored as glycogen for future use. Dysregulation.. View More»
DOI:
10.35248/2168-9296.25.14.391