Cell & Developmental Biology
Open Access
ISSN: 2168-9296
ISSN: 2168-9296
Chitoti Lumbala John*, Monde Wamunyima Mercy, Munsaka Sody, Aubrey Kalungia, Brown Kamanga, Kaampwe Muzandu, Sepiso Masenga, Kanyengo Wamunyima Christine
Background: People living with HIV have a greater prevalence of type 2 diabetes than the overall general population. This increasing occurrence can be attributed to a variety of causes, including the use of specific antiretroviral drugs, chronic metabolic dysfunction associated with HIV infection and lifestyle choices such as poor diet and physical inactivity. The growing number of people living with HIV and developing type 2 diabetes underscores the importance of identifying genetic factors that may influence the disease’s development. When blood glucose rises after a meal, the pancreas secretes insulin. Insulin then binds to its receptor causing translocation of GLUT4 from intracellular vesicles. This leads to blood glucose uptake into the cell's cytoplasm, inside the cell, glucose is converted to energy and stored as glycogen for future use. Dysregulation of this process may lead to insulin resistance and impaired glucose tolerance and ultimately cause type 2 diabetes.
Aim of the study: During the screening of the published data in a variety of journals, the review will encompass observational and molecular studies that explore the connection between GLUT4, risk factors for developing type 2 diabetes, HIV persons and prevalence. We will select studies published in English between now and January 2010, including research involving participants of every age, gender, race or stage of HIV infection.
Materials and methods: A comprehensive search will be conducted using exact search terms such as GLUT4 gene, polymorphism, type 2 diabetes, HIV, prevalence and risk factors. The method will include searching electronic databases such as PubMed, Embase, Google Scholar and Scopus to get articles for the study. The Prisma 2020 flow diagram will be utilized in the study to record screened articles, included articles and article identifications. Titles, abstracts and full-text publications will be evaluated for eligibility by two impartial reviewers and discrepancies will be settled by discussion. The quality of the studies such as case-control and cohorts will be done using the Newcastle-Ottawa scale based on the selection of study groups, compatibility of study groups and ascertaining the outcomes.
Conclusion: This systematic review procedure provides a structured framework for performing a complete examination of the literature on GLUT4 polymorphisms and T2D risk in HIV-positive persons, to improve our understanding of the genetic factors influencing metabolic problems in this population.
Published Date: 2025-04-18; Received Date: 2024-08-01