Journal of Clinical Chemistry and Laboratory Medicine
Open Access

Department Of Clinical Pathology, Mansoura University, Mansoura, Egypt

Publications

• Research   
  Osteopontin Rs9138 and Rs1126616 Gene Polymorphism in Egyptian Patients with Colorectal Carcinoma
  Author(s): Ehsan Rizk*, Mohammed El-Arman, Azza El-Baiomy, Tharwat Kandil, Shereen Mourad and Ola Elmam
  
  Background: Osteopontin (OPN) is a glycophosphoprotein produced by a variety of cells and has several important physiologic and pathologic roles including cancer pathogenesis through various signaling pathways. Genetic polymorphisms of OPN in 3'UTR and exon may be implicated in the carcinogenesis and progression of colonic carcinomas. Objectives: This study aimed to find whether OPN rs9138 and rs1126616 single nucleotide polymorphisms were associated with increased risk and progression of Colorectal Carcinoma (CRC). Subjects and methods: Randomized case control study conducted on 100 CRC patients and 100 apparently healthy subjects. All subjects were investigated for OPN rs9138 and rs1126616 genotyping and CEA, CA 19-9 and OPN plasma levels. The genotypes were assayed using Polymerase Chain Reaction-R.. View More»
  DOI: 10.35248/JCCLM.22.5.238

  Abstract HTML PDF