ISSN: 2576-1447
Dr, Ph.D, Department of Biomedical, Faculty of Medicine, Universitas Pelita Harapan Jl, Indonesia
I am P.Bei Tu, belonging to Department of Electrical Electronics Engineering, Syed Ammal Engineering College, Ramanathapuram, India, interested in the field of Wireless Mesh Network, multiradio, multichannel, channel allocation.
Research Article
Curcuminoids Suppress the Number of Transformed-Hepatocytes and Ki67 Expression in Mice Liver Carcinogenesis Induced by Diethylnitrosamine
Author(s): Atmodjo WL*, Larasati YO, Isbandiati D and Mathew G
Background: Curcuminoids has been reported to have strong anti-oxidant and anti-inflammatory effects, however the effect of curcuminoids to hepatocytes and their proliferation in DEN (Diethylnitrosamine) induced mice liver carcinoma model is still not yet been studied in detail.
Objection: To evaluate the effects of curcuminoids-containing diets in liver carcinoma mice induce with Diethylnitrosamine
Methods: Forty of 5 weeks old, male Balb/C mice were administered DEN as an injection and fed with basal diet; and another group injected with DEN and fed with 0.2% curcuminoids-containing diet. Dose of injection DEN is 75 mg/kg BW/week for 3 weeks, continued with 100 mg/kg BW/week for 3 continuous weeks. Five animals in each group were sacrificed at 20 and 32 weeks after the first injection of DEN. The liver sections were st.. View More»
DOI:
10.4172/2576-1447.1000112