Virology & Mycology
Open Access

Department of Biochemistry and Biotechnology, Genetic Engineering Laboratory, Oriental Institute of Science and Technology, Vidyasagar University, West Bengal, India

Publications

• Research   
  Coronavirus Nsp2 Protein Homologies to the Bacterial DNA Topoisomerase I and IV Suggest Nsp2 Protein is an Unique RNA Topoisomerase with Novel Target for Drug and Vaccine Development
  Author(s): Asit Kumar Chakraborty*
  
  COVID-19 is a deadly infectious (+) stranded RNA Virus which produces a 7098AA length polyprotein that degraded into sixteen polypeptides in infected human cells. As the Coronavirus infections now pandemic claiming >300000 peoples worldwide, discovery of molecular target is great. The biological functions of the Coronavirus non-structural nsp2 protein is unknown. BLAST search is the best method to understand the function of unknown protein on the basis of sequence homology among the known protein amino acid sequence available in the Genbank Database. Few type I DNA topoisomerases show RNA Topoisomerase activity and such activity was found in Nsp2 protein by homology search with Vibrio haemolyticus Type I and type IV DNA topoisomerase as well as E. coli DNA gyrase and DNA primase. The RNA topoisomearse activity of COVID-19 needed to release the RNA-RNA knots and.. View More»
  DOI: 10.35248/2161-0517.20.09.185

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