Immunome Research
Open Access
ISSN: 1745-7580
ISSN: 1745-7580
The Rappaport Faculty of Medicine, Technion, Israeli Institute of Technology, Haifa, Israel
Research Article
Systemic Sclerosis-Interstitial Lung Disease Characteristics and Survival Rates in a Long-term Follow-up
Author(s): Shiri Keret, Yolanda Braun-Moscovici, Anna Solomonov, Doron Markovits, Sami Giryes, Kohava Toledano, Yonit Tavor, Katya Dolnikov, Alexander Rozin, Elite Vainer Evgrafov, Hanna Dawood, Luda Guralnik and Alexandra Balbir-Gurman*
Objective: To assess the morbidity, mortality and prognostic factors of patients with Systemic Sclerosis (SSc) and Interstitial Lung Disease (ILD).
Methods: A retrospective analysis of prospectively collected data of SSc patients between the years 2000-2020. Data collection included demographic and clinical parameters, with repeated assessments of Forced Vital Capacity (FVC), Diffusing Capacity of the Lungs for Carbon Monoxide (DLCO), and Pulmonary Artery Pressure (PAP) in SSc-ILD patients.
Results: Among 446 SSc patients [367 (82.2%) female, mean age 46.5 years, 175 (39.2%) diffuse SSc [DcSSc]], 141 (31.6%) had SSc-ILD, 121 (27.1%) deceased, of which 74 (61.6%) patients died from SSc-related complication. SSc-ILD was associated with male sex, Arab descent, DcSSc, anti-topoisomerase antibodies, myopathy, and Pulmon.. View More»
DOI:
10.35248/1745-7580.23.19.226