Journal of Bone Research
Open Access
ISSN: 2572-4916
ISSN: 2572-4916
Hospital of the Support Group for Children and Adolescents with Cancer-GRAACC, Sao Paulo, Brazil
Research Article
Are Childhood-Onset Craniopharyngioma Patients at Risk for Low Bone Mass? Insights into Adiposity, Hypogonadism and Growth Hormone
Author(s): Patricia D. Cavalcanti Tosta-Hernandez, Andrea Cappellano, Marcelo de Medeiros Pinheiro and Angela M. Spinola-Castro
Background: Bone mass may be compromised in childhood-onset craniopharyngioma patients due to different
factors. The aim of this study was to evaluate the effect of adiposity, hypogonadism and growth hormone on bone
mass in craniopharyngioma patients.
Methods: A cross-sectional study of 46 patients, aged between 6.6 and 32.1 years, 7.5 years from diagnosis, 63%
male, 39.1% underwent surgery followed by cranial radiotherapy, assessed according to body fat, lumbar spine and
total body bone mineral density through dual energy X-ray absorptiometry, computed tomography scan-derived
abdominal adipose tissue, and adipokines by univariate and multivariate regression analyses.
Results: Craniopharyngioma patients presented with decreased lumbar spine and total body bone mass related to
therapy (cranial radiothe.. View More»
DOI:
10.35248/2572-4916.22.10.180