Journal of Clinical Chemistry and Laboratory Medicine
Open Access

Department of Anderson Clinical Genetics, Anderson Diagnostic Services Private Limited, No.26, Rajarathinam Street, Kilpauk, Chennai 600010, India

Publications

• Research Article   
  Analysis of Moonlighting Proteins Regulated by Curcumin and Resveratrol in Cancer
  Author(s): Venil N. Sumantran* and Anand Babu Kannadasan
  
  Multitasking Proteins or Moonlighting Proteins (MLP) play a major role in human disease and many are drug targets. MLPs have a single polypeptide with two different biochemical functions and often have different cellular localizations. Analysis of MultitaskProtDB-II and comparative toxicogenomics databases and Gene Ontology (GO) and STRING analysis, showed that curcumin and resveratrol regulate 3 groups of MLPs. Group 1 MLPs drive Epithelial Mesenchymal Transition (EMT), whereas MLPs in groups 2 and 3 regulate tumor growth and suppression, respectively. The 3 groups of MLPs form a complex self-regulating network due to regulatory interactions between MLPs and the presence of transcription factors (CTNNB1, p53, NRF2) with their regulators and targets. Curcumin and/or resveratrol downregulate MLPs which drive EMT (CTNNB1, FASN, SMADs 2,3,4, MECP2, MMP2, TGFჅ.. View More»
  DOI: 10.35248/2736-6588.23.6.274

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