Angiology: Open Access
Open Access

Department of Pharmacy, Hospital General Universitario Gregorio Marañón, Madrid, Spain

Publications

• Research Article   
  Safety and Effectiveness of a Shortened Regimen of Alprostadil (PGE1) with Large Infusion Dose, for Ischemic Manifestations of the Extremities in Real-World Clinical Practice
  Author(s): Teresa Cervera*, José Manuel Ligero and Ana de Lorenzo
  
  Objective: To analyse historical indications, tolerance, secondary effects and effectiveness of a treatment regimen with short interrupted cycles of large doses of PGE1 as well as possible factors that may influence the results in real world clinical practice in a tertiary hospital. Material and Methods: This is an observational, descriptive, retrospective study of all patients treated from 2013 to 2020 with high-doses of PGE1 in our hospital. Results: Forty five patients from 27 to 91 years old were treated for ischemic diseases, grouped into 6 types. Treatment caused side effects in 14 patients (31%) and has to be discontinued in 6 of them for intolerance (13% of total). Intolerance was associated with heart disease and advanced age. No short or long term complications were observed in these patients after discon.. View More»
  DOI: 10.35248/2329-9495.22.10.299

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