Journal of Antivirals & Antiretrovirals
Open Access
ISSN: 1948-5964
+44 1300 500008
ISSN: 1948-5964
+44 1300 500008
Department of Chemistry, Federal University of Technology, P.M.B. 704, Akure, Ondo State, Nigeria
Research Article
Derivatized Extracts from Aframomium melegueta K. Schum. and Vernonia amygdalina Delile Contain Organic Compounds that Showed Antiviral Effects against Atypical Fowl Pox Virus (FPV Kabete)
Author(s): Oladunmoye MK, Afolami OI*, Oladejo BO, Amoo IA and Osho BI
In this study, we tested for the antiviral potentials of derivatized extracts from two plants Aframomium melegute K. Schum. and Vernonia amygdalina Delile against atypical Fowl pox virus (FPV Kabete). Preliminary study on derivatized extracts from the plants showed that A. melegute extract contain two abundant phenols (benzaldehyde-3-hydroxy-4methoxy and butan-2-one-4-(3-hydroxy-2-methoxyphenyl) while the V. amygdalina extract contained Phytol and a nucleoside analogue Methyl-2-O-benzyl-d-arabinofuranoside as most abundant compounds. We determined the prophylactic and therapeutic efficacy of the derivatized extracts against the FPV in Embryonated Chick Eggs (ECEs) and also linked their antiviral properties to the activity of the most abundant compounds they contain. Results showed that the extracts had strong therapeutic and prophylactic efficacy against FPV. Summarily, the extract fr.. View More»