Journal of Clinical and Cellular Immunology

Journal of Clinical and Cellular Immunology
Open Access

ISSN: 2155-9899

Amany M. Tawfeik

Molecular immunology unit for Infectious Diseases, Department of Microbiology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt

  • Research Article   
    Association of CD4+ CD25+ FOXP3+ Regulatory T-cells and Human Papilloma Virus Infection in Egyptian Women with Breast Cancer
    Author(s): Amany M. Tawfeik, Ahmed Mora, Ahmed Osman, Manar M. Moneer, Nabila El-Sheikh and Mohamed Elrefaei*

    Several subsets of regulatory CD4+ T cells (CD4+ Tregs) have been described in peripheral blood and tumor microenvironment of breast cancer (BC) patients and may play a key role in the progression of BC. High-risk human papilloma virus (HPV) have a causal role in a significant proportion of cervical, and head, and neck tumors and may play an important role in evoking neoplasia in BC. In this study we assessed the prevalence of CD4+Tregs (CD4+ CD25+ FOXP3+ cells) and CD3+ CD8+ T cells by flow cytometry in peripheral blood from a total of 55 Egyptian women, including 20 treatment-naïve BC, 15 with breast benign lesions (BBL) and 20 healthy volunteers (HV). Highrisk HPV genotype type 16, 18, and 31 was investigated in breast tissue from all BC and BBL patients using Real- Time PCR. HPV was detected in 4 BC, but in none of BBL patients. The frequency of CD4+ Tregs was significantly h.. Read More»
    DOI: 10.35248/2155-9899.20.11:591.

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