Journal of Clinical Chemistry and Laboratory Medicine
Open Access
ISSN: 2736-6588
+44 1223 790975
ISSN: 2736-6588
+44 1223 790975
Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Rome, Italy
Research
In vitro Study Evaluating the Influence of Vehicle in the Permeability Process of a Topical Composition Containing Cannabis Sativa Oil, Escin, Bromelain, Glucosamine Sulphate, Methylsulfonylmethane, Methylsalicylate and Boswellia Extract, Designed for Local Treatment of Musculoskeletal Painful and Inflammatory Conditions
Author(s): Annalisa Curcio*, Fabiana Nano, Michele Pironti, Nicola Marchitto, Alberto Pannozzi, Lucia Laura Bilo, Adriana Romano and Gianfranco Raimondi
Objective: The aim of this study is to evaluate the influence of different vehicles in the permeability process of active
ingredients in a topical composition containing cannabis sativa seed oil enriched in Cannabidiol (CBD), escin,
bromelain, glucosamine sulphate, methylsulfonylmethane, methylsalicylate and Boswellia extract, designed for local
treatment of musculoskeletal painful and inflammatory conditions.
Methods: The same amount of each active ingredients (1% w/w) has been dissolved in four different vehicles
(G1: liquid paraffin, white petrolatum, cetostearyl alcohol, polyethylene glycol 1000; G2: water, propylene glycol,
carbomer; G3: water, phenoxyethanol, caprylyl glycol, decylene glycol, carbomer; G4: water, phenoxyethanol, caprylyl
glycol, decylene glycol, carbomer, glycerin). Permeability skin tests were carried .. View More»
DOI:
10.35248/jcclm.21.4.189