Journal of Antivirals & Antiretrovirals
Open Access
ISSN: 1948-5964
+44 1300 500008
ISSN: 1948-5964
+44 1300 500008
Department of Microbiology, University of Al-Neelain, Khartoum, Sudan
Research Article
Molecular Detection of Interleukin 28B Gene rs8099917 Polymorphism in chronic HCV Patients from Khartoum State, Sudan
Author(s): Mohamed Ibrahim, Abdel Rahim M El Hussein, Isam M Elkhidir, Dina N Abdelrahman and Khalid A Enan*
Background: Hepatitis C virus (HCV) infection represents a major health burden According to the world health organization (WHO) there are more than 170 million people infected worldwide and 3-4 million new infections are estimated per year. Recent studies have demonstrated the role of interleukin B 28(IL B 28) polymorphism in predicting the treatment induced and spontaneous clearance from hepatitis C virus (HCV) infection and genome-wide association studies have shown that single nucleotide polymorphism (SNPs) near interleukin 28B gene are good predictors of response to treatment. The present study aimed to isolate and identify IL 28 B gene rs8099917 polymorphism from HCV infected individuals DNA.
Methods: This cross-sectional study was performed on 50 blood samples from patients with chronic HCV infection as detected by ELISA kit (RIBA-11 a.. View More»