Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
+44 1223 790975
ISSN: 2155-9899
+44 1223 790975
Yoshihiro Konishi
National Tottori Medical Center,
876 Mitsu, Tottori 689-0203
Japan
Review Article
Cytokines and Cytokine Receptors Involved in the Pathogenesis of Alzheimer’s Disease
Author(s): Tomone Nagae, Kiho Araki, Yuki Shimoda, Lucia I. Sue, Thomas G. Beach and Yoshihiro KonishiTomone Nagae, Kiho Araki, Yuki Shimoda, Lucia I. Sue, Thomas G. Beach and Yoshihiro Konishi
Inflammatory mechanisms are implicated in the pathology of Alzheimer’s disease (AD). However, it is unclear whether inflammatory alterations are a cause or consequence of neurodegeneration leading to dementia. Clarifying this issue would provide valuable insight into the early diagnosis and therapeutic management of AD. To address this, we compared the mRNA expression profiles of cytokines in the brains of AD patients with “non-demented individuals with AD pathology” and non-demented healthy control (ND) individuals. “Non-demented individuals with AD pathology” are referred to as high pathology control (HPC) individuals that are considered an intermediate subset between AD and ND. HPC represents a transition between normal aging and early stage of AD, and therefore, is useful for determining whether neuroinflammation is a cause or consequence of AD pathol.. View More»
DOI:
10.4172/2155-9899.1000441