Journal of Clinical and Cellular Immunology

Journal of Clinical and Cellular Immunology
Open Access

ISSN: 2155-9899

Yonggang Sha

Yonggang Sha

Durham, North Carolina

  • Review Article
    New Insights into S-nitrosylation in Multiple Sclerosis
    Author(s): Yonggang ShaYonggang Sha

    S-nitrosylation is a biologically relevant post-translational protein modification with signaling consequence. In eukaryotes, a large number of proteins have been identified as S-nitrosylation targets. Derangement in protein S-nitrosylation has been implicated in the pathogenesis of a number of different disease entities including Multiple Sclerosis (MS). A growing body of evidence has shown that Nitric oxide (NO) plays a critical role in MS. NO and other reactive nitrogen species (RNS) are involved in neuroinflammation and neurodegeneration in MS. Signaling by RNS is carried out mainly by S-nitrosylation of critical cysteine residues in targeted proteins. In recent years, newer roles in MS have been attributed to RNS. These roles relate to S-nitrosylation of cysteines in proteins which has emerged as a potential new paradigm in signal transduction and regulation of protein function. .. Read More»
    DOI: 10.4172/2155-9899.1000147

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