Clinical & Experimental Cardiology
Open Access
ISSN: 2155-9880
ISSN: 2155-9880
Xiushan Wu
Indiana
Research Article
Knockdown and Overexpression of Nmnat in the Heart Improve Cardiac Function When Accompanied by Early Repeated Exercise in Aging Drosophila
Author(s): Xiaoxuan Xia, Lan Zheng, Xu Tian, Dengtai Wen, Yue Feng, Hui Wang and Xiushan WuXiaoxuan Xia, Lan Zheng, Xu Tian, Dengtai Wen, Yue Feng, Hui Wang and Xiushan Wu
Aim: To determine whether early exercise in the form of instinctive upward walking can mitigate the negative effects of cardiac aging in Drosophila with cardiac-specific Nmnat Knockdown and overexpression.
Methods: Flies were given exercise periods of 2 h per day, 5 days a week for 3 weeks starting when they were 2 days old. The heart model was used in conjunction with M-mode echocardiography traces to analyze cardiac function. Exercise capacity was assessed using a climbing index, and the survival rate was calculated with respect to the age of each subject upon death.
Results: Cardiac-specific Nmnat knockdown severely compromised cardiac function with age by increased incidence of arrhythmias and decreased fractional with extreme dilation. The repeated exercise regimen was found to mitigate the deterioration of.. View More»
DOI:
10.4172/2155-9880.1000584