Journal of Clinical and Cellular Immunology

Journal of Clinical and Cellular Immunology
Open Access

ISSN: 2155-9899

+44 1223 790975

Xiaodong Zhang

Xiaodong Zhang
Yerkes Imaging Center, Yerkes National Primate Research Center,
954 Gatewood Rd, Atlanta, GA 30329

  • Review Article
    Quantitative MRI Measures in SIV-Infected Macaque Brains
    Author(s): Xiaodong Zhang and Chunxia LiXiaodong Zhang and Chunxia Li

    Multiple MRI modalities including Diffusion Tensor Imaging (DTI), perfusion MRI, in vivo MR Spectroscopy (MRS), volumetric MRI, contrast-enhanced MRI, and functional MRI have demonstrated abnormalities of the structural and functional integrity as well as neurochemical alterations of the HIV-infected central nervous system (CNS). MRI has been proposed as a robust imaging approach for the characterization of the stage of progression in HIV infection. However, the interpretation of the MRI findings of HIV patients is complicated by the fact that these clinical studies cannot readily be controlled. Simian immunodeficiency virus (SIV) infected macaques exhibit neuropathological symptoms similar to those of HIV patients, and are an important model for studying the course of CNS infection, cognitive impairment, and neuropathology of HIV disease as well as treatment efficacy. MRI of non-huma.. View More»
    DOI: 10.4172/2155-9899.S7-005

    Abstract PDF

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