Organic Chemistry: Current Research
Open Access
ISSN: 2161-0401
+44 1478 350008
ISSN: 2161-0401
+44 1478 350008
Virupakshi Prabhakar
SVR Engineering College,
Anantapuramu (JNTU-A), Nandyal-518 501, Kurnool, Andhra Pradesh
India
Research Article
Synthesis, Structural Elucidation and Anti-Bacterial Evaluation of Some Novel Heterocyclic Molecules Derived from Thieno [2,3-d] Pyrimidine as a Core Unit
Author(s): Virupakshi Prabhakar, Sangu Jagadish Babu, Sangu VN Lalitha Siva Jyothi, Sangu VN Lahari and Venkateswarlu BandiVirupakshi Prabhakar, Sangu Jagadish Babu, Sangu VN Lalitha Siva Jyothi, Sangu VN Lahari and Venkateswarlu Bandi
A series of novel 4-(3,5-dimethyl-1H-pyrazol-1-yl)-2-substituted phenyl/Heterocyclic Thieno[2,3-d] Pyrimidine (8 a-j) derivatives were synthesized by a facile Five-step procedure that afforded advantages of mild reaction conditions, simple protocol and good yields. The structures of the final compounds were confirmed by IR, NMR, EI-MS. The final compounds were screened for their anti-bacterial activity against Bacillus subtilis and Staphylocouccus aureus from Gram positive group of bacteria and Escherichia coli and Klebsiella pneumonia from Gram negative group of bacteria and antifungal activity against Candida albicans and Aspergillus flavus. Anti-bacterial and anti-fungal activities were Evaluated and compared with the standard drugs Such as Amoxicillin and Ketoconazole. From anti-bacterial and antifungal activity screening results, it has been observed that compounds 8i, 8h, 8e and.. View More»