Journal of Clinical and Cellular Immunology

Journal of Clinical and Cellular Immunology
Open Access

ISSN: 2155-9899

+44 1223 790975

Trine N. Jørgensen

Trine N. Jørgensen
NE40, Lerner Research Institute, Cleveland Clinic Foundation,

  • Review Article
    Pro- and Anti-inflammatory Neutrophils in Lupus
    Author(s): Evan Der, Abhishek Trigunaite, Ayesha Khan and Trine N. JørgensenEvan Der, Abhishek Trigunaite, Ayesha Khan and Trine N. Jørgensen

    A hallmark of SLE is the presence of elevated levels of circulating anti-nuclear autoantibodies specific towards chromatin, histones or dsDNA. Understanding the regulation of antibody production is therefore of utmost importance in understanding lupus pathogenesis. Spearheaded by the identification of accumulating immunosuppressive neutrophils in cancer patients, the nature and function of neutrophils have expanded from a uniform pro-inflammatory cell population to a heterogeneous population of cells with pro-inflammatory or immunosuppressive capacities. While much is known about pro-inflammatory neutrophils and the likely pathogenic function of such cells in lupus, a potential role for immunosuppressive neutrophils in protecting genetically predisposed individuals has only recently emerged. For example, SLE-derived neutrophils spontaneously produce type I interferons (IFNα), st.. View More»
    DOI: 10.4172/2155-9899.1000239

    Abstract PDF

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