Journal of Depression and Anxiety

Journal of Depression and Anxiety
Open Access

ISSN: 2167-1044

Tridip Chatterjee

Tridip Chatterjee
Department of Molecular Biology and Human Genetics, Institute of Genetic Engineering, Human Genetics, Medicine and Genomic Science,
30A Thakurhat Road, Kolkata-700128, West Bengal

  • Review Article
    An Insight into the Cellular Mechanisms of Addiction to Psychostimulants
    Author(s): Ashim Kumar Basak and Tridip ChatterjeeAshim Kumar Basak and Tridip Chatterjee

    Natural rewards like food, sex etc are evaluated as pleasureable elements or essential for the survival of a mammal due to the interaction of dopamine (DA) released by ventral tegmental area (VTA) on nucleus accumbens (NAc) and other targets in an interconnected neuronal network in brain called ‘reward circuit. Psychostimulants induce prolonged and much greater interaction of DA with its targets and develop the drug related memory in lieu of the memories of natural rewards and induce motor activities required for drug acquisition. Long term potentiation (LTP), a major contributor of synaptic plasticity, occurs in many components of the reward circuit due to both acute and chronic drug exposures, resulting in the morphological changes of neurons that may underlie drug related memory acquisition. Potentiation may occur in VTA DA neurons, medium spiny neurons (MSNs) of NAc, prefron.. View More»
    DOI: 10.4172/2167-1044.1000238

    Abstract PDF

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