Journal of Clinical and Cellular Immunology
Open Access

Toshio Tanaka

Publications

• Review Article
  Immunotherapy of Tocilizumab for Rheumatoid Arthritis
  Author(s): Toshio Tanaka and Tadamitsu KishimotoToshio Tanaka and Tadamitsu Kishimoto
  
  Rheumatoid arthritis (RA) is a chronic inflammatory disease, characterized by persistent joint inflammation, systemic inflammation and immunological abnormalities. Because IL-6 plays a major role in the development of these characteristics, IL-6 blockade may reasonably be expected to constitute a novel therapeutic strategy for the treatment of RA. Phase III clinical trials of a humanized anti-human IL-6 receptor monoclonal antibody, tocilizumab, have demonstrated its outstanding clinical efficacy, either as monotherapy or in combination with disease-modifying antirheumatic drugs, for moderate to severe active RA patients. Although tocilizumab is currently recommended as a second-line biologic for RA patients whose response to one or more of TNF inhibitors is inadequate, further clinical studies including head-to-head comparative studies, and clarification of the mechanisms through whi.. View More»
  DOI: 10.4172/2155-9899.S6-001

  Abstract PDF

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