Journal of Clinical and Cellular Immunology
Open Access

Toshiharu Fujiyama

Publications

• Short Communication
  Th1 Chemokine CXCL10 and Alopecia Areata: The Possible Target for the Treatment of Alopecia Areata
  Author(s): Taisuke Ito, Toshiharu Fujiyama and Yoshiki TokuraTaisuke Ito, Toshiharu Fujiyama and Yoshiki Tokura
  
  Alopecia areata (AA) is an organ-specific and cell-mediated autoimmune disease. Recent studies have suggested the most important effector cell of AA is NKG2D+CD8+T cells, and outer root sheath (ORS) cells highly express NKG2D ligands, such as MICA, in AA lesions. T lymphocytes densely surround lesional hair bulbs, which is histologically referred to as “swarm of bees”. Immunohistochemical and real-time RT-PCR studies reveal that hair follicles of acute-phase AA expressed a high level of Th1-associated chemokine CXCL10. In the skin lesions of acute-phase AA, CXCR3+CD4+ and CXCR3+CD8+ T cells infiltrated in the juxta-follicular area. In chronic-phase AA, CXCR3+CD8+ T cells dominated the infiltrate around hair bulbs, possibly contributing to the prolonged state of hair loss. Lymphocytes obtained from a lesional skin of acute-phase AA contained CXCR3+CD4+ and CXCR3+CD8+ T cell.. View More»
  DOI: 10.4172/2155-9899.1000453

  Abstract PDF

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