Journal of Clinical and Cellular Immunology

Journal of Clinical and Cellular Immunology
Open Access

ISSN: 2155-9899

+44 1223 790975

Thomas G. Beach

Thomas G. Beach

Tanzania

Publications
  • Review Article
    Cytokines and Cytokine Receptors Involved in the Pathogenesis of Alzheimer’s Disease
    Author(s): Tomone Nagae, Kiho Araki, Yuki Shimoda, Lucia I. Sue, Thomas G. Beach and Yoshihiro Konishi Tomone Nagae, Kiho Araki, Yuki Shimoda, Lucia I. Sue, Thomas G. Beach and Yoshihiro Konishi

    Inflammatory mechanisms are implicated in the pathology of Alzheimer’s disease (AD). However, it is unclear whether inflammatory alterations are a cause or consequence of neurodegeneration leading to dementia. Clarifying this issue would provide valuable insight into the early diagnosis and therapeutic management of AD. To address this, we compared the mRNA expression profiles of cytokines in the brains of AD patients with “non-demented individuals with AD pathology” and non-demented healthy control (ND) individuals. “Non-demented individuals with AD pathology” are referred to as high pathology control (HPC) individuals that are considered an intermediate subset between AD and ND. HPC represents a transition between normal aging and early stage of AD, and therefore, is useful for determining whether neuroinflammation is a cause or consequence of AD pathol.. View More»
    DOI: 10.4172/2155-9899.1000441

    Abstract PDF

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