Clinical & Experimental Cardiology
Open Access
ISSN: 2155-9880
+44 1300 500008
ISSN: 2155-9880
+44 1300 500008
Thananya Boonyasirinant
Siriraj Hospital,
Bangkok
Thailand
Research Article
Efficacy and Safety of Lorazepam Relative to Chest Pain, Delirium, Arrhythmias, and Sleep Satisfaction in Patients with Acute Coronary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Study
Author(s): Saowanee Naowapanich, Pattanaporn Supina, Potchanard Tancharoon-Ouangjan, Phinaphorn Sungkomkeang, Apirom Laocharoenkeat and Thananya BoonyasirinantSaowanee Naowapanich, Pattanaporn Supina, Potchanard Tancharoon-Ouangjan, Phinaphorn Sungkomkeang, Apirom Laocharoenkeat and Thananya Boonyasirinant
Background: Patients with anxiety commonly occurs after an Acute Coronary Syndrome (ACS). The standard treatment to relieve anxiety is the sedation drugs. Lorazepam can effectively relieve the symptoms and affect the symptoms confusion and mood changes.Objective and methods: To investigate the efficacy and safety of lorazepam relative to chest pain, delirium, arrhythmias, and sleep satisfaction compared to placebo in patients with acute coronary syndrome. This prospective, randomized, double-blind clinical trial included ACS patients who were treated during the April 2016 to June 2018 study period. The study population was randomized into the lorazepam group or the placebo group. Subjects received either lorazepam 0.5 mg oral QD or placebo, which was administered for at least 7 days from the first day until discharge or transfer.Re.. View More»