Clinical & Experimental Cardiology
Open Access
ISSN: 2155-9880
ISSN: 2155-9880
Syeda H Afroze
Tanzania
Review Article
Mechanosensing and Regulation of Cardiac Function
Author(s): David E Dostal, Hao Feng, Damir Nizamutdinov, Honey B Golden, Syeda H Afroze, Joseph D Dostal, John C Jacob, Donald M Foster, Carl Tong, Shannon Glaser and Gerilechaogetu FNU
David E Dostal, Hao Feng, Damir Nizamutdinov, Honey B Golden, Syeda H Afroze, Joseph D Dostal, John C Jacob, Donald M Foster, Carl Tong, Shannon Glaser and Gerilechaogetu FNU
The role of mechanical force as an important regulator of structure and function of mammalian cells, tissues, and organs has recently been recognized. However, mechanical overload is a pathogenesis or comorbidity existing in a variety of heart diseases, such as hypertension, aortic regurgitation and myocardial infarction. Physical stimuli sensed by cells are transmitted through intracellular signal transduction pathways resulting in altered physiological responses or pathological conditions. Emerging evidence from experimental studies indicate that β1-integrin and the angiotensin II type I (AT1) receptor play critical roles as mechanosensors in the regulation of heart contraction, growth and leading to heart failure. Integrin link the extracellular matrix and the intracellular cytoskeleton to initiate the mechanical signalling, whereas, the AT1 receptor could be activated by mech.. View More»
DOI:
10.4172/2155-9880.1000314