Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
+44 1223 790975
ISSN: 2155-9899
+44 1223 790975
Suzanne T. Ildstad
Jewish Hospital, Distinguished Professor of Transplantation, Distinguished University Scholar, Professor of Surgery,
570 South Preston Street, Suite 404, Louisville, Kentucky 40202-1760
Tanzania
Review Article
Chimerism and Tolerance in Solid Organ Transplantation
Author(s): Kadiyala Ravindra, Joseph Leventhal, David Song and Suzanne T. IldstadKadiyala Ravindra, Joseph Leventhal, David Song and Suzanne T. Ildstad
Transplantation has become standard of care to treat end-organ failure, replacing a failed organ with a functioning one. However, the toxicity of the immunosuppressive agents that are critical to graft maintenance is significant. Complications associated with the use of these agents include opportunistic infections, cardiovascular disorders, an increased rate of malignancy, and renal failure. As a result, approaches to induce tolerance to transplanted organs and/or minimize immunosuppression are a major priority. This review summarizes the role of chimerism in tolerance induction, presenting an historic perspective and ending on clinical protocols actively underway... View More»
DOI:
10.4172/2155-9899.S9-003