Journal of Clinical and Cellular Immunology

Journal of Clinical and Cellular Immunology
Open Access

ISSN: 2155-9899

+44 1223 790975

Su Deng

Su Deng


  • Review Article
    MicroRNAs in Prostate Cancer: Small RNAs with Big Roles
    Author(s): Ping Mu, Su Deng and Xiaozhou FanPing Mu, Su Deng and Xiaozhou Fan

    MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression either by mediating translational repression or reducing the stability of a target mRNA. Deregulated expression of miRNAs is a common feature of human cancers and a growing body of evidence demonstrates the role of miRNAs as either oncogenes or tumor suppressors. Many miRNAs have been reported to be associated with the pathogenesis of primary prostate cancer (PCa) and the development of castration resistant prostate cancer (CRPC). PCa is the most common cancer and second leading cause of cancer death in American men. Although patients with primary PCa can be treated with chemotherapy and hormone therapy, many of them will develop resistance to conventional therapies and progress to a more sever condition called CRPC, which remains one of the most difficult cancers to treat. Since em.. View More»
    DOI: 10.4172/2155-9899.1000315

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