Clinical & Experimental Cardiology
Open Access

Stephan B Felix

Publications

• Research Article
  Reduced Cardiac Performance after Differential Pharmacological Stress in Streptozotocin-Induced Diabetic Rats
  Author(s): Alexander Riad, Dirk Westermann, Stefan B Felix, Heinz P Schultheiss and sten Tschope Alexander Riad, Dirk Westermann, Stefan B Felix, Heinz P Schultheiss and sten Tschope
  
  The development of heart failure including disturbed cardiac stress response is a main complication of diabetes mellitus (DM). In the present study we characterized in vivo the cardiac stress response in the often used streptozotocin (STZ) rat model. We analysed left ventricular (LV) performance of STZ-diabetic rats under basal and pharmacological stress conditions by recording pressure-volume loops using a microconductance catheter at two different time points. Under basal conditions, STZ induces after two weeks impaired LV systolic and diastolic dysfunction indexed by decreased LV pressure and dp/dtmax as well as decreased cardiac stiffness and dp/dtmin leading to decreased cardiac output. This cardiac phenotype behaved at least in part progressively up to six weeks after STZ injection. Intravenously infusion of dobutamine led to a dose-dependent depression of LV performance two and.. View More»
  DOI: 10.4172/2155-9880.1000108

  Abstract PDF

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