Journal of Clinical and Cellular Immunology

Journal of Clinical and Cellular Immunology
Open Access

ISSN: 2155-9899

+44 1223 790975

Solomon Odemuyiwa

Publications
  • Research Article
    Expression and Regulation of Cholecystokinin Receptor in the Chicken’s Immune Organs and Cells
    Author(s): Seham El-Kassas, Solomon Odemuyiwa, George Hajishengallis, Terry D Connell and Toufic O NasharSeham El-Kassas, Solomon Odemuyiwa, George Hajishengallis, Terry D Connell and Toufic O Nashar

    Cholecystokinin (CCK) is a neuropeptide that affects growth rate in chickens by regulating appetite. CCK peptides exert their function by binding to two identified receptors, CCKAR and CCKBR in the GI tract and the brain, respectively, as well as in other organs. In mammals, CCK/CCKAR interactions affect a number of immunological parameters, including regulation of lymphocytes and functioning of monocytes. Thus, food intake and growth can potentially be altered by infection and the resulting inflammatory immune response. It is uncertain, however, whether chicken express CCKAR in immune organs and cells, and, if so, whether CCKAR expression is regulated by pathogen derived inflammatory stimuli. Herein, we identify expression of CCKAR protein in chicken peripheral blood mononuclear cells (PBMC) including monocytes, and expression of the CCKAR gene in PBMC, thymus, bursa, and spleen, in .. View More»
    DOI: 10.4172/2155-9899.1000471

    Abstract PDF

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