Andrology-Open Access
Open Access

Shun-mei Deng

Publications

• Research Article
  Increased Oxidative DNA Damage in Seminal Plasma of Infertile Men with Varicocele
  Author(s): Qi-ling Wang, Li-xin Tang, Shun-mei Deng, Yun-ge Tang and Li-xin ZhengQi-ling Wang, Li-xin Tang, Shun-mei Deng, Yun-ge Tang and Li-xin Zheng
  
  Objective: To investigate the oxidative DNA damage in the seminal plasma and spermatozoa of infertile men with varicocele and to evaluate the potential relationship between oxidative DNA damage and varicocele. Methods: This case-control study recruited 180 infertile men with varicocele and 199 infertile men without varicocele and 168 fertile male control subjects. Semen parameters, seminal plasma 8-hydroxy-2-deoxyguanosine (8-OHdG) and sperm DNA Fragmentation Index (DFI) were assessed. Results: Compared to the infertile men without varicocele and control subjects, infertile men with varicocele exhibited lower sperm concentration, lower progressive motility, lower vitality and lower percentage of normal morphology (all P=0.0001). The seminal content of 8-OHdG and sperm DFI were higher in infertile men with varicocel.. View More»
  DOI: 10.4172/2167-0250.1000119

  Abstract PDF

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