Journal of Clinical and Cellular Immunology
Open Access

Shohreh Issazadeh-Navikas

Publications

• Research Article
  NKT Cell Subsets and Proinflammatory Cytokine Changes in Mice as a Result of a Natural Pasteurella pneumotropica Infection
  Author(s): Yawei Liu and Shohreh Issazadeh-NavikasYawei Liu and Shohreh Issazadeh-Navikas
  
  CD1d-dependent natural killer T (NKT) cells play an important protective role in a variety of autoimmune, allergic, tumor, and infectious diseases, but there are several controversial reports. The balance in subsets of NKT cells and their activation status prior to induction of such diseases could play a critical role in the clinical outcome. Pasteurella pneumotropica is a commonly found bacterium in laboratory rodents. Because this infection is often asymptomatic and hence can go undetected, and given different levels of acceptable health status in different animal facilities, this infection could impact the outcome of reported scientific studies. We report that subclinical natural infection with P. pneumotropica significantly affects the balance among different subsets of NKT cells. While the major CD1ddependent population, i.e., CD4+ NKT cells, was not .. View More»
  DOI: 10.4172/2155-9899.1000117

  Abstract PDF

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