Journal of Clinical and Cellular Immunology

Journal of Clinical and Cellular Immunology
Open Access

ISSN: 2155-9899

+44 1223 790975

Shobhana Sivaramakrishnan

Shobhana Sivaramakrishnan
West Virginia University School of Medicine,
Morgantown, WV 26506

  • Review Article
    Rebound from Inhibition: Self-Correction against Neurodegeneration?
    Author(s): Shobhana Sivaramakrishnan and William P. LynchShobhana Sivaramakrishnan and William P. Lynch

    Neural networks play a critical role in establishing constraints on excitability in the central nervous system. Several recent studies have suggested that network dysfunction in the brain and spinal cord are compromised following insult by a neurodegenerative trigger and might precede eventual neuronal loss and neurological impairment. Early intervention of network excitability and plasticity might therefore be critical in resetting hyperexcitability and preventing later neuronal damage. Here, the behavior of neurons that generate burst firing upon recovery from inhibitory input or intrinsic membrane hyperpolarization (rebound neurons) is examined in the context of neural networks that underlie rhythmic activity observed in areas of the brain and spinal cord that are vulnerable to neurodegeneration. In a non-inflammatory rodent model of spongiform neurodegenerative disease triggered b.. View More»
    DOI: 10.4172/2155-9899.1000492

    Abstract PDF

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