Cloning & Transgenesis
Open Access
ISSN: 2168-9849
ISSN: 2168-9849
Shirong Yu
China
Research Article
Association of HLA-DRB1*1201/02, DRB1*0701/02, DQA1*0302 and DQB1*0303 Alleles with population Uygur patients of vitiligo
Author(s): Xiaojing Kang, Lvjiao Peng, Junqin Liang, Li Chai, Shirong Yu and Xiujuan WuXiaojing Kang, Lvjiao Peng, Junqin Liang, Li Chai, Shirong Yu and Xiujuan Wu
Vitiligo is associated with different human leukocyte antigens (HLAs), but the relationship of HLAs and Uygur population people is unknown. The study aimed to investigate whether there is an association between HLADRB1* 1201/02, DRB1*0701/02, DQA1*0302, and DQB1*0303 and the incidence of vitiligo in a Chinese Uygur population and further evaluate their effect on the clinical features of vitiligo. A total of 308 Chinese Uygur patients with vitiligo and 310 healthy controls were included in the study. HLA-DRB1*1201/02, DRB1*0701/02, DQA1*0302 and DQB1*0303 allele distribution was investigated by polymerase chain reaction (PCR), the sequence-specific primer method. Family history, clinical types, phase, etc. were evaluated. The data were analyzed by the chi-square test. A significant difference was found in the distribution of HLA-DRB1*1201/02, DRB1*0701/02, DQA1*0302, and DQB1*0303 betw.. View More»
DOI:
10.4172/2168-9849.1000157