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Journal of Clinical and Cellular Immunology

Journal of Clinical and Cellular Immunology
Open Access

ISSN: 2155-9899

+44 1223 790975

Shamala Moodley

Shamala Moodley

Umlazi, KwaZulu-Natal
South Africa

Publications
  • Research Article
    Transplacental Infection of HIV-1 and the Associated Risk Factors In Utero
    Author(s): Shamala MoodleyShamala Moodley

    Background: Identifying risk factors in “in utero” transmission of human immunodeficiency virus type 1 (HIV-1) is important when designing preventive interventions. Several lines of evidence suggest that Natural Killer (NK) cells have an important role in antiviral defence. However, the Human Leucocyte Antigen-G (HLA-G) molecules are inhibitory of these cell-mediated immune responses and could, therefore, promote the propagation of HIV-1 infection across the placental interface thus increasing the risk of vertical transmission. Study design: A total of 55 women were enrolled into the study. Tests for viral loads, CD+4 counts, Natural Killer cells, p24 and HLA-G1 expression were performed. Using logistic regression analyses, a study of the risk factors were undertaken. Results: Variables associated with in u.. View More»
    DOI: 10.4172/2155-9899.1000195

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