Cloning & Transgenesis
Open Access
ISSN: 2168-9849
ISSN: 2168-9849
Seongsoo Hwang
Republic of Korea
Research Article
Overexpression of Porcine Kit Gene in Transgenic Mice Does not Affect Melanogenesis
Author(s): Jin Seop Ahn, Ga Ram Kim, Seong Hong Jang, Dong-Hwan Kim, Seongsoo Hwang, Incheol Cho and Jeong-Woong LeeJin Seop Ahn, Ga Ram Kim, Seong Hong Jang, Dong-Hwan Kim, Seongsoo Hwang, Incheol Cho and Jeong-Woong Lee
The Kit gene is proto-oncogene, encoded stem cell factor and involved in melanocyte development. Also, Kit is expressed in epidermis and proliferation of melanoblasts which occur to pigmentation in skin, eyes and other tissues. Here we established porcine Kit genes overexpressed transgenic mice. The role of Kit gene was regulation in melanogensis remains unclear in porcine. Therefore, present study aims to ectopic expression porcine Kit gene in pigmentation of skin tissues. Our results showed that no effect on melanogenesis in ectopic Kit gene overexpressed transgenic mice. Further studies on Kit gene will provide insight into other specific roles in porcine and mice species. .. View More»
DOI:
10.4172/2168-9849.1000159