Journal of Fertilization: In Vitro - IVF-Worldwide, Reproductive Medicine, Genetics & Stem Cell Biol
Open Access
ISSN: 2375-4508
+44 1478 350008
ISSN: 2375-4508
+44 1478 350008
Selma Ulusal
Turkey
Short Communication
Cytogenetic Analysis and Thrombophilia-Associated Gene Mutations of Couples with Recurrent Miscarriage
Author(s): Emine Ikbal Atli, Hakan Gurkan, Hilmi Tozkir, Yasemin Ozen, Selma Ulusal, Engin Atli, Gulizar Fusun Varol and Cenk SayinEmine Ikbal Atli, Hakan Gurkan, Hilmi Tozkir, Yasemin Ozen, Selma Ulusal, Engin Atli, Gulizar Fusun Varol and Cenk Sayin
Introduction: Three or more pregnancy losses before 20 weeks of gestation are usually defined as recurrent miscarriage. Parental chromosomal translocations, thrombophilic gene polymorphisms, autoimmune factors, uterine, endocrine factors associated with recurrent miscarrige (RM). Factor V Leiden, prothrombin gene mutation G20210A, protein S/Protein C/antithrombin deficiency and MTHFR mutations responsible for hereditary thrombophilia and has been included to keep a very common practice of RM pathogenesis. This study aimed to determine the incidence of these factors believed to be the effects of RM. Materials and methods: All patients were took a full genetic analysis; full genetic examination and pedigree drawing was done to exclude known nonchromosomal causes of the anomaly. Cytogenetic analysis was done for 635 patients. The study included peripheral lymphocyte culture by a standard.. View More»
DOI:
10.4172/2375-4508.1000189