Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Saurav Brahmachari
Department of Neurological Sciences, Division of Neuroscience, Rush University Medical Center.
Chicago, USA
Dr. Saurav Brahmachari is from Division of Neuroscience, Rush University Medical Center, Chicago. His research focuses on understanding the molecular mechanisms underlying the pathogenesis of inflammatory neurodegenerative diseases like Parkinson’s disease (PD) and Multiple sclerosis (MS) with special emphasis on identification of novel molecular targets to develop better therapeutic intervention. The major questions that he currently investigating are: 1) how protein aggregates in PD and alpha-synucleinopathies known as Lewy Body (LB) and Lewy Neurites (LN) that primarily consist of α-synuclein, cause the death of dopamine producing neuronal cells in a specific region of the ventral midbrain called substantia nigra, 2) How immune cells become activated in the periphery, infiltrate into central nervous system (CNS) and cause inflammation in the brain in MS, 3) How inflammation in the CNS is related to specific loss of cells in PD and MS, and 4) what modification could be done to rescue the cell death and thereby neurodegeneration in PD and MS. The first part of his studies involve the generation and characterization of novel mouse models in order to understand the molecular mechanisms of pathogenesis and to identify the molecular targets that could possibly be modulated. The second part involves screening of compounds that could modulate the activities of those targets and subsequent use of these compounds in our mouse models to study the therapeutic effects. His teams discoveries could lead to the development of better therapy for PD and MS.
Neurochemistry, Molecular Mechanisms of Neurodegeneration, Glia and Neuroinflammation, Neuropharmacology, Neuroimmunology.