Journal of Clinical and Cellular Immunology

Journal of Clinical and Cellular Immunology
Open Access

ISSN: 2155-9899

+44 1223 790975

Salvador Nares

Salvador Nares
College of Dentistry,
Chicago, Illinois

  • Research Article
    miR-24 Regulates Macrophage Polarization and Plasticity
    Author(s): Jezrom B. Fordham, Afsar R. Naqvi and Salvador NaresJezrom B. Fordham, Afsar R. Naqvi and Salvador Nares

    Objective: MicroRNAs (miRNA) are ubiquitous regulators of human biology and immunity. Previously, we have demonstrated an inhibitory role for miR-24 in the phagocytosis of Escherichia coli and Staphylococcus aureus bioparticles and the induction of cytokine secretion in response to lipopolysaccharide (LPS) of the same origin; also, we have identified divergent and convergent miRNA responses to LPS from the periodontopathic pathogens Aggregatibacter actinomycetemcomitams (Aa) and Porphyromonas gingivalis (Pg), and revealed cigarette smoke extract as an environmental modifier of Pg LPS structure (Pg CSE) impacting macrophage miRNA responses. This study was designed to investigate the role of miR-24 on macrophage polarization and plasticity. Methods: Primary human macrophages were differentiated from CD14+ monocytes isolated fro.. View More»
    DOI: 10.4172/2155-9899.1000362

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