Immunome Research
Open Access
ISSN: 1745-7580
+44-20-4587-4809
ISSN: 1745-7580
+44-20-4587-4809
Sahar Obi
Sudan
Research Article
Immunoinformatic Approach for Epitope-Based Peptide Vaccine against Lagos Rabies Virus Glycoprotein G
Author(s): Omar Hashim Ahmed, Arwa Abdelhalim, Sahar Obi, Khoubieb Ali Abd_elrahman, Ahmed Hamdi and Mohammed A.HassanOmar Hashim Ahmed, Arwa Abdelhalim, Sahar Obi, Khoubieb Ali Abd_elrahman, Ahmed Hamdi and Mohammed A.Hassan
Background: Lagos rabies virus belongs to lyssavirus genus responsible for meningoencephalomyelitis in mammals that affect millions of people around the world and causes thousands of human deaths every year, to the best of our knowledge there is no peptide vaccine designed for Lagos rabies virus. The resulting peptide vaccine is expected to be more immunogenic and less allergic than conventional biochemical vaccines. The aim of this study was to design an Insilco peptide vaccine for Lagos rabies virus using Immunoinformatic tools.
Methods and Materials: Sequences of glycoprotein G of Lagos rabies virus was retrieved from NCBI, the retrieved sequences were then treated using different Immunoinformatic tools for B cell to find out the most conserved, surface and antigenic epitopes, and for T cell to find conserved peptides and to test their bindi.. View More»
DOI:
10.4172/1745-7580.1000137