Journal of Molecular Imaging & Dynamics

Journal of Molecular Imaging & Dynamics
Open Access

ISSN: 2155-9937

Sabahat Sohail

Sabahat Sohail


  • Research Article
    In Silico Study of miR-132 with mRNA of Acetylcholinesterase to Investigate the Binding Affinity for Interaction
    Author(s): Sabahat SohailSabahat Sohail

    Acetylcholinesterase (AChE) is a key enzyme in central nervous system which hydrolaze neurotransmitter acetylcholine (ACh) at cholinergic brain synapses. High expression of AChE in brain and muscles is responsible for diverse neurological conditions leading from neuromuscular, neurodegenerative and neuropsychological diseases. miRNA-132 is a non-coding RNA molecule which help to regulate the expression level of number of genes involved in neurological development, angiogenesis and synaptic transmission. However, miR-132 is the only miR so far that has been experimentally validated as targeting AChE, with consequences on inflammatory responses. Various bioinformatics tools like MODELLER, I-Tasser, ModeRNA, 3D-Dart, ERRAT, ProSA and Rampage were employed for AChE, miR-132 and mRNA model building and their validations. The binding affinities of these macromol.. View More»
    DOI: 10.4172/2155-9937.1000144

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