ISSN: 2157-7595
						Ryota Matsuzawa 
	
					    												
Japan						                            
                            
						
 Mini Review
												Frailty and Survival in Patients with End-Stage Renal Disease 						
Author(s): Ryota Matsuzawa and Atsuhiko Matsunaga
Ryota Matsuzawa and Atsuhiko Matsunaga
             
						
												
				 Frailty is highly prevalent in patients with end-stage renal disease who require hemodialysis therapy. Frailty has been proposed by Fried and colleagues, and predicts poor outcomes in hemodialysis patients. Muscle weakness is a major component of frailty. We previously performed a single-center, prospective, observational, cohort study among 190 Japanese patients undergoing hemodialysis and examined the association of muscle weakness in lower extremity with survival. As a result, muscle weakness in the lower extremities had a significant negative effect on survival in these patients. Muscle weakness is reversibly activated by exercise training or physical therapy in patients undergoing hemodialysis. Therefore, exercise training for patients with end-stage renal disease could improve their prognosis via correction of muscle weakness. In this paper, we reviewed muscle weakness, which is.. View More»
				  
												DOI:
												 10.4172/2157-7595.1000227