Journal of Clinical and Cellular Immunology

Journal of Clinical and Cellular Immunology
Open Access

ISSN: 2155-9899

+44 1223 790975

Roy Carambula

Roy Carambula


  • Review Article
    Why Don’t We Have a Vaccine Against Autoimmune Diseases? - A Review
    Author(s): Ken S Rosenthal, Roy Carambula and Daniel H ZimmermanKen S Rosenthal, Roy Carambula and Daniel H Zimmerman

    This review examines some of the reasons why we don’t have a vaccine against autoimmune diseases and highlights the progress that has been made. Many autoimmune diseases, such as rheumatoid arthritis (RA), multiple sclerosis (MS) and type 1 diabetes (T1D), are driven by autoimmune T cell responses. Unlike vaccines for most infectious diseases, which elicit antibody responses, are intended for immuno-naïve individuals and considered preventative, a vaccine for an autoimmune disease must be therapeutic and resolve or control the on-going autoimmune response and condition in the diseased host. Despite these differences, many of the same considerations for infectious disease vaccines must also be addressed to develop a therapeutic vaccine for autoimmune diseases. The disease initiator/triggers, antigens and autoantigens, nature of the immunopathogenic and protective/therapeutic.. View More»

    Abstract PDF

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