Andrology-Open Access

Andrology-Open Access
Open Access

ISSN: 2167-0250

Rosália Sá

Rosália Sá
Laboratory of Cell Biology, Multidisciplinary Unit for Biomedical Research (UMIB), Abel Salazar Institute for the Biomedical Sciences (ICBAS), University of Porto (UP),
Porto
Portugal

Publications

  • Research Article
    Assessing Male Reproductive Toxicity during Drug Development
    Author(s): Mario Sousa, Carolina Ferreira, Ana Rabaca and Rosália Sa Mario Sousa, Carolina Ferreira, Ana Rabaca and Rosália Sa

    Pharmaceutical development is a crucial research field that attends to the population healthcare needs, comprising several preclinical and clinical steps before the approval of a new compound. Interestingly, the lack of efficacy and toxicity are known major failure causes during pharmaceutical drug development. Toxicity screening is therefore a mandatory procedure during pharmaceutical development. Renal and hepatic toxicity are the most common toxicity matters encountered during the development of new compounds. Nonetheless, the male reproductive system may also be a target for drug toxicity. However, developmental and reproductive toxicology testing is rarely performed both in pre-clinical and clinical trial phases. As a result, there are several risks for human fertility brought on by putative toxic chemical compounds. As there is a low incidence of reproductive and testicular toxi.. View More»
    DOI: 10.4172/2167-0250.1000185

    Abstract PDF

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