Journal of Fertilization: In Vitro - IVF-Worldwide, Reproductive Medicine, Genetics & Stem Cell Biol
Open Access
ISSN: 2375-4508
+44 1478 350008
ISSN: 2375-4508
+44 1478 350008
Raoul Orvieto
Sheba Medical Center,
Ramat Gan 52621
Israel
Research Article
The Role of GnRH-Analogues used in Elderly (>38 yrs) Patients Undergoing Controlled Ovarian Hyperstimulation for IVF
Author(s): Jacob Ashkenazi, Itai Bar-Hava, Simion Meltcer, Jacob Rabinson, Eyal Y Anteby and Raoul OrvietoJacob Ashkenazi, Itai Bar-Hava, Simion Meltcer, Jacob Rabinson, Eyal Y Anteby and Raoul Orvieto
Objectives: To examine the influence of type of GnRH-analogue used, on reproductive outcome of elderly patients (> 38 years old) undergoing controlled ovarian hyperstimulation (COH) for IVF.
Patients and Methods: We studied 2436 consecutive cycles, 1369 in the agonist group and 1067 in the antagonist group. Infertility-treatment-related variables and pregnancy rates were compared between young (<38 years) and elderly patients and between those undergoing the GnRH-agonist or antagonist COH protocols.
Results: While a significantly higher pregnancy rate was observed in young patients undergoing the GnRH-agonist as compared to the GnRH-antagonist COH protocols (30.1% vs 21.1%, respectively; p<0.001), no difference was demonstrated in elderly patients.
Conclusions: The long GnRH agonist suppressive protocol has a clear advantage over the GnRH antagon.. View More»
DOI:
10.4172/2375-4508.1000128