Journal of Molecular Imaging & Dynamics
Open Access
ISSN: 2155-9937
ISSN: 2155-9937
Ralph A. Bundschuh
Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universität München,
Ismaninger Str. 22, 81675 Munich
Germany
Research Article
Non-Negative Matrix Factorization Based Input Function Extraction for Mouse Imaging in Small Animal PET - Comparison with Arterial Blood Sampling and Factor Analysis
Author(s): Dominik Schulz, Arne Tapfer, Andreas Buck, Sybille Reeder, Matthias Miederer, Eliane Weidl, Sibylle I. Ziegler, Markus Schwaiger and Ralph A. BundschuhDominik Schulz, Arne Tapfer, Andreas Buck, Sybille Reeder, Matthias Miederer, Eliane Weidl, Sibylle I. Ziegler, Markus Schwaiger and Ralph A. Bundschuh
Objectives: Retrieving the accurate time-tracer activity concentration curve of the blood (arterial input function) is mandatory for performing bio kinetic model analysis of dynamic PET data. Especially in small rodents, gathering the input function remains an active area of research as no generally applicable solution was found so far. While surgically catheterizing blood vessels of rodents is possible, it is labour intensive and time resolution of blood sampling is restricted due to the limited amount of overall blood and the procedure of blood withdrawal itself. Obtaining the input function from the PET images themselves seems thus to be favourable, but suffers from several factors, one of them being spill-in of adjacent tissues. Particularly in mice and for [18F]FDG, the spill-in complicates using the time-activity curve (TAC) from a region of interest (ROI) over .. View More»
DOI:
10.4172/2155-9937.1000108