Journal of Nanomedicine & Biotherapeutic Discovery
Open Access

Rajapakse RMG

Publications

• Research Article
  Synthesis of Unstable Vaterite Polymorph of Porous Calcium Carbonate Nanoparticles, Encapsulation of Anticancer Drug Cisplatin, Studying Release Kinetics for Safe, Targeted Delivery and Slow Release
  Author(s): Dunuweera SP and Rajapakse RMGDunuweera SP and Rajapakse RMG
  
  Cisplatin is a commonly used anticancer drug which is the first generation of platinum-based anticancer drugs developed. The cis configuration enables the binding of the coordination complex to one or two DNA strand (s) and thereby crosslinking the DNA strands triggering the cells to die in a programmed manner. It is used to treat various types of cancers such as small cell lung cancer, ovarian cancer, bladder cancer, cervical cancer, and germ cell tumours. When administered into blood, cisplatin reacts with thiol containing proteins present in blood plasma thus reducing its bioavailability, increasing cytotoxicity and it is associated with numerous side effects including nephrotoxicity, neurotoxicity, nausea, vomiting and ototoxicity. In order to increase the bioavailability and to reduce dosage and cytotoxic effects to healthy cells thermodynamically unstable vaterite form of Porous.. View More»
  

  Abstract PDF

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